
| 2012 | Named a Top 100 hospital for the fourth time |
| 2011 | U.S. News and World Report names St. Luke's a high-performing hospital |
| 2011 | Helen G. Nassif Community Cancer Center opened |
| 2010 | IRPE Gold Award - First hospital in state to achieve gold level |
| 2010 | St. Luke's Cancer Care earns Commission on Cancer designation |
| 2010 | Press Ganey Top Improver Award for patient satisfaction |
| 2010 | Received Get With The Guidelines - Heart Failure Gold Performance Achievement Award from the American Heart Association and Get With the Guidelines - Stroke Gold Performance Achievement Award from the American Stroke Association. |
| 2010 | Chest Pain Center Accreditation from the Society of Chest Pain Centers |
| 2010 | Named a Top 100 Hospital for the third time |
| 2010 | Designated a Blue Distinction Center for knee and hip replacement |
| 2009 | Awarded Magnet status by the ANCC |
| 2009 | St. Luke's Marion Campus opened |
| 2009 | St. Luke's opened new Emergency Department |
| 2008 | St. Luke's Children's Campus in Hiawatha opened |
| 2008 | First hospital in Iowa to acquire the Robotic Catheter System to treat heart rhythm disorders |
| 2008 | First pediatric hospitalist program in Cedar Rapids began at St. Luke's |
| 2008 | Helen G. Nassif Pavilion opened |
| 2007 | Named a Press Ganey Success Story Award Winner for patient satisfaction |
| 2007 | St. Luke's new Physical Medicine and Rehabilitation unit opened |
| 2007 | First in Iowa to install SOMATOM Definition CT scanner |
| 2006 | First hospitalist program in Cedar Rapids began at St. Luke's. |
| 2006 | 10,000 open-heart surgeries performed at St. Luke's |
| 2006 | Named a Top 100 Hospital for second consecutive year |
| 2006 | First hospital in Iowa to receive the CARF Inpatient Stroke Specialty Program accreditation |
| 2005 | First robot-assisted surgery performed at a Cedar Rapids hospital |
| 2005 | St. Luke's named a Top 100 Hospital |
| 2001 | St. Luke's recognized as a Top 100 Stroke Hospital |
| 2001 | Helen G. Nassif Center for Women's & Children's Health opened |
| 2000 | Nassif Heart Center opened |
| 1998 | Surgery Center Cedar Rapids opened |
| 1995 | First Cedar Rapids hospital to put in cardiac stents |
| 1994 | St. Luke's joined Iowa Health System |
| 1983 | First cardiac rehabilitation facility in eastern Iowa opened |
| 1983 | Birth Care Center established |
| 1983 | SurgiCare for outpatient surgery opened |
| 1981 | Lifeguard air ambulance program arrived |
| 1978 | First open-heart surgery performed at a Cedar Rapids hospital |
| 1977 | Newborn Intensive Care Unit opened |
| 1972 | First total joint replacement performed at a Cedar Rapids hospital |
| 1972 | Family Practice Residency program initiated |
| 1972 | St Luke's and University of Iowa Hospitals and Clinics established the Iowa's only emergency medicine residency program |
| 1966 | St. Luke's Cardiac Care Unit began operation |
| 1960 | Intensive Care Unit opened and east wing completed |
| 1951 | St. Luke's main hospital expansion completed |
| 1948 | Women's Auxiliary organized |
| 1944 | School of X-ray Technology started |
| 1925 | Cornerstone laid for west wing |
| 1924 | Medical staff organized and St. Luke's recognized as a "standardized" hospital by the American College of Surgeons |
| 1914 | Cedar Rapids' first caesarean delivery |
| 1892 | Nursing school founded |
| 1884 | Cornerstone laid |